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AdipoGen Life Sciences
Xanthorrhizol
220
CHF
CHF 220.00
In stock
AG-CN2-0090-M0011 mgCHF 220.00
| Product Details | |
|---|---|
| Synonyms | 1,3,5,10-Bisabolatetraen-2-ol |
| Product Type | Chemical |
| Properties | |
| Formula | C15H22O |
| MW | 218.3 |
| CAS | 30199-26-9 |
| Source/Host Chemicals | Isolated from Curcuma xanthorrhiza. |
| Purity Chemicals | ≥97% (NMR) |
| Appearance | Colorless to light yellow oil. |
| Solubility | Soluble in DMSO or ethanol. |
| Identity | Determined by 1H-NMR, 13C-NMR and MS. |
| InChi Key | FKWGCEDRLNNZOZ-GFCCVEGCSA-N |
| Smiles | C[C@H](CCC=C(C)C)C1=CC=C(C)C(O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Shows calcium-antagonistic and vasorelaxant activity [1,3].
- Antibacterial [2].
- Anti-inflammatory. Potent COX-2 and inducible nitric oxide (iNOS; NOS II) inhibitor [4,5,9].
- Hepatoprotective [5, 6].
- Anticancer compound. Apoptosis inducer [7,8,10,12].
- Neuroprotective antioxidant [8].
- Antifungal [11].
Product References
- Effect of xanthorrhizol, xanthorrhizol glycoside and trachylobanoic acid isolated from Cachani complex plants upon the contractile activity of uterine smooth muscle: H. Ponce-Monter, et al.; Phytother. Res. 13, 202 (1999)
- Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens: J.K. Hwang, et al.; Fitoterapia 71, 321 (2000)
- Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta: M.G. Campos, et al.; Life Sci. 67, 327 (2000)
- Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells: S.K. Lee, et al.; J. Environ. Pathol. Toxicol. Oncol. 21, 141 (2002)
- Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription: S.H. Kim, et al.; Toxicol. Appl. Pharmacol. 196, 346 (2004)
- Phosphorylation of c-Jun N-terminal Kinases (JNKs) is involved in the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity: K.O. Hong, et al.; Arch. Toxicol. 79, 231 (2005)
- Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells: N. Ismail, et al.; Anticancer Res. 25, 2221 (2005)
- Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia: C.S. Lim, et al.; J. Neurosci. Res. 82, 831 (2005)
- Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells: T. Handayani, et al.; Anticancer Res. 27, 965 (2007)
- Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-acti: W.Y. Chung, et al.; Carcinogenesis 28, 1224 (2007)
- In Vitro antimycotic activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. against opportunistic filamentous fungi: Y. Rukayadi & J.K. Hwang; Phytother. Res. 21, 434 (2007)
- Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in Xanthorrhizol induced DNA fragmentation in HepG2 cells involving Bcl-2 family proteins: BBRC 420, 834 (2012)