Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Apicidin
75
CHF
CHF 75.00
In stock
AG-CN2-0087-M0011 mgCHF 75.00
AG-CN2-0087-M0055 mgCHF 300.00
| Product Details | |
|---|---|
| Synonyms | cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]; OSI-2040 |
| Product Type | Chemical |
| Properties | |
| Formula |
C34H49N5O6 |
| MW | 623.8 |
| CAS | 183506-66-3 |
| Source/Host Chemicals | Isolated from fungus Fusarium sp. |
| Purity Chemicals | ≥98% (HPLC, TLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in ethanol or DMSO. |
| InChi Key | JWOGUUIOCYMBPV-LQJYRIKDSA-N |
| Smiles | [H][C@]12CCCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CC1=CN(OC)C3=C1C=CC=C3)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antiprotozoal [1].
- Potent inhibitor of histone deacetylase (HDAC) [1,2].
- Inhibits proliferation [2,3].
- Induces cell cycle arrest at the G1 phase [2].
- Induces hyperacetylation of histone H4 [5].
- Apoptosis inducer [4,8,9].
- Potent anti-angiogenic compound [5-7].
- Decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines [3].
- Autophagy inducer in oral squamous cell carcinoma (OSCC) cells [8].
- Promotes either self-renewal or differentiation of embryonic stem cells [10].
Product References
- Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase: S.J. Darkin-Rattray, et al.; PNAS 93, 13143 (1996)
- Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin: J.W. Han, et al.; Cancer Res. 60, 6068 (2000)
- Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor: J.S. Kim, et al.; BBRC 281, 866 (2001)
- Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells: S.H. Kwon, et al.; J. Biol. Chem. 277, 2073 (2002)
- Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells: J. Hong, et al.; Cancer Lett. 189, 197 (2003)
- Regulation of the HIF-1alpha stability by histone deacetylases: S.H. Kim, et al.; Oncol. Rep. 17, 647 (2007)
- Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells: T. Ueda, et al.; Int. J. Mol. Med. 19, 301 (2007)
- Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells: M.Y. Ahn, et al.; Oral. Oncol. 47, 1032 (2011)
- Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cγ1- and Ca(2+)-dependent pathway in mouse Neuro-2a neuroblastoma cells: J.H. Choi, et al.; Apoptosis 17, 1340 (2012)
- Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming: A. Kretsovali, et al.; Stem Cells Int. 2012, 1 (2012)
Related Products
