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AdipoGen Life Sciences
Thiocolchicoside
55
CHF
CHF 55.00
In stock
AG-CN2-0076-M0011 mgCHF 55.00
AG-CN2-0076-M0055 mgCHF 95.00
AG-CN2-0076-M02525 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | BRN 0072205; NSC 147755; Coltramyl; 10-thio-Colchicoside; 2-Demethoxy-2-glucosidoxythiocolchicine |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H33NO10S |
| MW | 563.6 |
| Merck Index | 14: 9324 |
| CAS | 602-41-5 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Yellow solid. |
| Solubility | Soluble in water or ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | LEQAKWQJCITZNK-MSQQGMGVSA-N |
| Smiles | COC1=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C2CCC(NC(C)=O)C3=CC(=O)C(SC)=CC=C3C2=C1OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist.
- Weak nicotinic acetylcholine receptor agonist.
- Muscle relaxant.
- Anti-inflammatory. Has analgesic properties.
- Shows strong epileptogenic and convulsant activity.
- Anticancer compound through inhibition of NF-κB and NF-κB-regulated gene products
- Apoptosis inducer.
- Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-κB signaling pathway.
- Therapeutic option for the management of bone metastatic disease.
Product References
- Affinity of thiocolchicoside and thiocolchicoside analogues for the postsynaptic GABA receptor site: K. Biziere, et al.; Eur. J. Pharmacol. 75, 167 (1981)
- Review of the toxicology, pharmacodynamics and pharmacokineticss of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions: J.M. Janbroers; Acta Ther. 13, 221 (1987)
- Interaction of thiocolchicoside with [3H]strychnine binding sites in rat spinal cord and brainstem: M. Cimino, et al.; Eur. J. Pharmacol. 318, 201 (1996)
- Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat: G. Sechi, et al.; Seizure 12, 508 (2003)
- Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain: F. Tüzün, et al.; Joint Bone Spine 70, 356 (2003)
- The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system: M. Carta, et al.; Neuropharmacology 51, 805 (2006)
- Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes: M.P. Mascia, et al.; Eur. J. Pharmacol. 558, 37 (2007)
- Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer: S. Reuter, et al.; Cancer Prev. Res. 3, 1462 (2010)
- Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug: S. Reuter, et al.; Br. J. Pharmacol. 165, 2127 (2012)
- Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption? O. Micheau, et al.; Br. J. Pharmacol. 165, 2124 (2012)
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