AdipoGen Life Sciences

Cytisine

CHF 30.00
In stock
AG-CN2-0075-M0055 mgCHF 30.00
AG-CN2-0075-M02525 mgCHF 65.00
More Information
Product Details
Synonyms (-)-Cytisine; Baptitoxin; NSC 407282; BRN 0083882
Product Type Chemical
Properties
Formula

C11H14N2O

MW 190.2
CAS 485-35-8
Source/Host Chemicals Isolated from Laburnum anagyroides seeds.
Purity Chemicals ≥99% (HPLC)
Appearance Yellow solid.
Solubility Soluble in ethanol, benzene, acetone or ethyl acetate. Sparingly soluble in water or methanol.
Identity Determined by 1H-NMR.
InChi Key ANJTVLIZGCUXLD-DTWKUNHWSA-N
Smiles O=C1C=CC=C2C3CNCC(C3)CN12
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Pyridine-like alkaloid.
  • Nicotine agonist.
  • Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors.
  • Shows analgesic, antihypertensive and inotropic activities.
  • Used for smoking cessation.
  • Might be used for binge-like ethanol drinking cessation.
  • Iron-chelator and hydroxyl radical scavanger.
  • Has antidepressant properties.
  • Used in forensics in novel surface molecular imprinting techniques.
Product References
  1. Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit: R.L. Papke & S.F.  Heinemann; Mol. Pharmacol. 45, 142 (1994)
  2. Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35: B.W. Wenger, et al.; J. Pharmacol. Exp. Ther. 281, 905 (1997)
  3. Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998)
  4. Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors: L.M. Houlihan, et al.; J. Neurochem. 78, 1029 (2001)
  5. Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003)
  6. Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes: Y.E. Slater, et al.; Neuropharmacology 44, 503 (2003)
  7. Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy: P. Tutka & W. Zatonski; Pharmacol. Rep. 58, 777 (2006) (Review)
  8. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007)
  9. Cytisine for smoking cessation: a research agenda: J.F. Etter, et al.; Drug Alcohol Depend. 92, 3 (2008) (Review)
  10. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors: Y.F. Li, et al.; Auton. Neurosci. 154, 14 (2010)
  11. Preparation and recognition performance of cytisine alkaloid-imprinted material prepared using novel surface molecular imprinting technique: B. Gao, et al.; J. Sep. Sci. 33, 1338 (2010)
  12. Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice: R.K. Sajja & S. Rahman; Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 257 (2011)
  13. Cytisine improves smoking cessation: W. Osman; Thorax 67, 573 (2011)
  14. Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors: E.G. Perez, et al.; Nat. Prod. Rep. 29, 555 (2012) (Review)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.