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AdipoGen Life Sciences
Debromohymenialdisine
150
CHF
CHF 150.00
In stock
AG-CN2-0068-C100100 µgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | DBH; DBHA-SKF; SKF 108753 |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H11N5O2 |
| MW | 245.2 |
| CAS | 75593-17-8 and 125118-55-0 |
| Source/Host Chemicals | Isolated from sponge Axinella carteri. |
| Purity Chemicals | ≥90% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | JYRJOQGKGMHTOO-VURMDHGXSA-N |
| Smiles | NC1=NC(=O)\C(N1)=C1/CCNC(=O)C2=C1C=CN2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site [1].
- Cytotoxic and insecticidal [2].
- G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor [3, 4, 6].
- Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins [3, 4].
- MAP kinase kinase 1 (MEK-1) inhibitor [5].
- Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic [7].
- Potential anti-Alzheimer agent [7].
Product References
- Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats: M. DiMartino, et al.; Inflamm. Res. 44, S123 (1995)
- Bioactive alkaloids from the tropical marine sponge Axinella carteri: A. Supriyono, et al.; Z. Naturforsch. C 50, 669 (1995)
- Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001)
- G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin: N.T. Rundle, et al.; J. Biol. Chem. 276, 48231 (2001)
- Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002)
- G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004)
- Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol: Y.F. Song, et al.; Mar. Biotechnol. 13, 868 (2011)
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