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AdipoGen Life Sciences
Phenylmethylene hydantoin
230
CHF
CHF 230.00
In stock
AG-CN2-0041-M0011 mgCHF 230.00
| Product Details | |
|---|---|
| Synonyms | PMH; 5(4-Hydroxybenzylidene)hydantoin |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H8N2O3 |
| MW | 204.2 |
| CAS | 80171-33-1 |
| Source/Host Chemicals | Isolated from an unidentifed marine sponge. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Greenish solid. |
| Solubility | Soluble in ethanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | UPDDIBZITPTASO-YVMONPNESA-N |
| Smiles | OC1=CC=C(\C=C2/NC(=O)NC2=O)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anticancer compound [2, 3, 5, 6].
- Chemopreventive [2, 3, 5, 6, 7].
- Shows anti-metastatic activity in prostate cancer cells through enhancement of cell-cell adhesion [2, 3].
- Anti-invasive compound [5, 6, 7].
- Glycogen synthase kinase-3β (GSK-3 β) inhibitor [4].
Product References
- The synthesis of amino-acids: Piperidine and diethylamine as catalysts in the condensation of aromatic aldehydes with hydantoins: W.J. Boyd & W. Robson; Biochem. J. 29, 542 (1935)
- Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis: G.V. Shah, et al.; Mol. Cancer Ther. 8, 509 (2009)
- Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products: M. Mudit, et al.; Bioorg. Med. Chem. 17, 1731 (2009)
- The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling: M.A. Khanfar, et al.; Bioorg. Med. Chem. 17, 6032 (2009)
- Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis: M.A. Khanfar & K.A. El Sayed; Eur. J. Med. Chem. 45, 5397 (2010)
- Phenyl-methylene hydantoins alter CD44-specific ligand binding of benign and malignant prostate cells and suppress CD44 isoform expression: K. Yang, et al.; Am. J. Transl. Res. 2, 88 (2010)
- Methods for evaluation of structural and biological properties of antiinvasive natural products: M. Mudit, et al.; Meth. Mol. Biol. 716, 55 (2011)