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Sauchinone

AG-CN2-0032-M001 1 mg $30.00
AG-CN2-0032-M005 5 mg $90.00
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Additional Information

Product Data
Synonyms 1′-Epimer dihydrocarpanone
Properties
Formula C20H20O6
MW 356.4
CAS 177931-17-8
Source/Host Chemicals Isolated from Saururus chinensis.
Purity ≥98% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in DMSO or chloroform.
InChi Key GMTJIWUFFXGFHH-WPAOEJHSSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Hepatoprotective antioxidant [1, 2, 9].
  • Anti-inflammatory. Suppresses NF-kB p65 activity [3, 5].
  • Neuroprotective. Apoptosis inhibitor [4].
  • Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation [6].
  • Antiseptic [7].
  • AMP-activated kinase (AMPK) activator [8].
  • Akt phosphorylation inhibitor [10].
  • Arginase II inhibitor [11].

Product References

  1. Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000)
  2. Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000)
  3. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003)
  4. Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003)
  5. Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003)
  6. Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007)
  7. Protective effect of lignans against sepsis from the roots of Saururus chinensis: C.S. Seo, et al.; Biol. Pharm. Bull. 31, 523 (2008)
  8. Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury: Y.W. Kim, et al.; Free Radic. Biol. Med. 47, 1082 (2009)
  9. Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway: H.Y. Kay, et al.; Br. J. Pharmacol. 163, 1653 (2011)
  10. Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells: E.Y. Yang, et al.; Int. Immunopharmacol. 14, 188 (2012)
  11. Arginase II inhibitory activity of phenolic compounds from Saururus chinensis: C. J. Lim, et al.; Bull. Korean Chem. Soc. 33, 3079 (2012)
  12. Pharmacokinetics and pharmacodynamics of promising Arginase Inhibitors: K.S. Abdelkawy, et al.; Eur. J. Drug Metab. Pharmacokinet. 42, 355 (2017) Review
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