Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
G418 . sulfate
35
CHF
CHF 35.00
In stock
AG-CN2-0030-M250250 mgCHF 35.00
AG-CN2-0030-M500500 mgCHF 45.00
AG-CN2-0030-G0011 gCHF 60.00
AG-CN2-0030-G0055 gCHF 190.00
| Product Details | |
|---|---|
| Synonyms | Geneticin; Antibiotic G418; BRN 1669188 |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H40N4O10 . 2H2SO4 |
| MW | 496.6 . 196.1 |
| CAS | 108321-42-2 |
| RTECS | CB9378500 |
| Source/Host Chemicals | Isolated from Micromonospora rhodorangea. |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water (up to 50 mg/ml). |
| Biological Activity |
Assay: ≥700 μg/mg |
| InChi Key | BRZYSWJRSDMWLG-UHFFFAOYSA-N |
| Smiles | [H]N(C)C1C(O)C(OC2C(N)CC(N)C(OC3OC(C(C)O)C(O)C(O)C3N)C2O)OCC1(C)O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis [1, 3, 4, 6].
- Apoptosis inducer [5].
- Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II [2].
- Antiviral [7, 8].
Product References
- Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization: G.H. Wagman, et al.; Antimicrob. Agents Chemother. 6, 144 (1974)
- Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C: J.C. Morris, et al.; J. Biol. Chem. 271, 15468 (1996)
- Addition of G418 and other aminoglycoside antibiotics to mammalian cells results in the release of GPI-anchored proteins: M. Kung, et al.; FEBS Lett. 409, 333 (1997)
- The effects of G418 on the growth and metabolism of recombinant mammalian cell lines: C.A. Yallop & I. Svendsen; Cytotechnology 35, 101 (2001)
- Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418: Q.H. Jin, et al.; Cell. Mol. Life Sci. 61, 1816 (2004)
- Expression and distribution of HSP27 in response to G418 in different human breast cancer cell lines: L. Qian, et al.; Histochem. Cell Biol. 126, 593 (2006)
- Antiviral activity of geneticin against bovine viral diarrhoea virus: A.V. Birk, et al.; Antivir. Chem. Chemother. 19, 33 (2008)
- Antiviral activity of geneticin against dengue virus: X.G. Zhang, et al.; Antiviral Res. 83, 21 (2009)
Related Products
