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Ferutinin (high purity)

AG-CN2-0007-M001 1 mg $35.00
AG-CN2-0007-M005 5 mg $100.00
AG-CN2-0007-M010 10 mg $160.00
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Product Datasheet
MSDS
Catalogs
Products > Chemical > Metabolism

Additional Information

Product Data
Synonyms 4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en; Tefestrol
Properties
Formula C22H30O4
MW 358.5
CAS 41743-44-6
Source/Host Chemicals Semisynthetic.
Purity ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, acetone, dichloromethane or ethyl acetate.
InChi Key CYSHNJQMYORNJI-YUVXSKOASA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
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Product Description

  • Potent, naturally occuring non-steroid estrogenic compound.
  • Tool to promote mitochondrial calcium overload and to promote calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) [1, 3, 4].
  • Strong agonist for estrogen receptor (ER)α and agonist/antagonist for ERβ [2, 8].
  • Calcium ionophoretic [4, 11]
  • Apoptosis modulator [4].
  • Antiproliferative [5, 7].
  • Increases nitric oxide synthase activity and phosphoinositides breakdown in nervous tissue [6].
  • Shows aphrodisiac and anti-sexual impotence activities [6].
  • Anti-osteoporotic. Prevents osteoporosis caused by severe estrogen deficiency [9].
  • Modest AChE inhibitor [10].

Product References

  1. Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997)
  2. Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002)
  3. Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003)
  4. Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line: A. Macho, et al.; Biochem. Pharmacol. 68, 875 (2004) 
  5. Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines: F. Poli, et al.; Phytother. Res. 19, 152 (2005)
  6. Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat: T. Colman-Saizarbitoria, et al.; J. Ethnopharmacol. 106, 327 (2006)
  7. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines: R. Alkhatib, et al.; Phytochemistry 69, 2979 (2008)
  8. The phytoestrogen ferutinin affects female sexual behavior modulating ERalpha expression in the hypothalamus: P. Zanoli, et al.; Behav. Brain Res. 199, 283 (2009)
  9. Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis: M. Ferretti, et al.; J. Anat. 217, 4 (2010)
  10. Identification of non-alkaloid acetylcholinesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae): S. Dall'acqua, et al.; Fitoterapia 81, 1208 (2010)
  11. Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973)
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