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Zerumbone

AG-CN2-0004-M010 10 mg $45.00
AG-CN2-0004-M050 50 mg $180.00
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Additional Information

Product Data
Synonyms (2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one
Properties
Formula C15H22O
MW 218.3
CAS 471-05-6
Source/Host Chemicals Isolated from the underground parts of Curcuma zerumbet.
Purity ≥99% (HPLC)
Appearance Solid white crystals or powder.
Solubility Soluble in DMSO or 100% ethanol.
Other Product Data Preparation of 1 mM stock solution: Dissolve 0.218 mg zerumbone in 1 ml solvent.
InChi Key GIHNTRQPEMKFKO-SKTNYSRSSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Description

  • Chemopreventive probe [1, 2].
  • Apoptosis inducer [3, 4].
  • Potent anti-tumor compound [2-4].
  • Anti-inflammatory activity by downregulating COX-2 and iNOS expression via modulation of NF-κB activation [5, 6].
  • Antinociceptive [7].
  • Probe to study chemokine receptors functioning [8].
  • Potential therapeutic agent for osteoporosis and cancer-associated bone loss [9].

Product References

  1. Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet: T. Tanaka, et al.; Life Sci. 69, 1935 (2001)
  2. Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. S. Yodkeeree, et al.; Cancer Res. 69, 6581 (2009) 
  3. Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells: S.I. Abdelwahab, et al.; Leuk. Res. Epub ahead of print (2010)
  4. Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo: G.C. Huang, et al.; Planta Med. 71, 219 (2005)
  5. Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines: A. Murakami, et al.; Biofactors 21, 95 (2004)
  6. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice: M. R. Sulaiman, et al.; Fitoterapia 81, 855 (2010)
  7. Preliminary analysis of the antinociceptive activity of zerumbone: M. R. Sulaiman, et al.; Fitoterapia 80, 230 (2009)
  8. Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells: B. Sung, et al.; Cancer Res. 68, 8938 (2008)
  9. Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice: B. Sung, et al.; Cancer Res. 69, 1477 (2009)
  10. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion: Y. Takada, et al.; Oncogene 24, 6957 (2005)
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