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Skyrin

AG-CN2-0001-M001 1 mg $150.00
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Additional Information

Product Data
Synonyms Rhodophyscin; Endothianin; 4,4′-Biemodin
Properties
Formula C30H18O10
MW 538.5
CAS 602-06-2
Source/Host Chemicals Isolated from fungus Talaromyces sp.
Purity ≥97% (HPLC)
Appearance Orange to dark red solid.
Solubility Soluble in 100% ethanol or DMSO.
InChi Key MQSXZQXHIJMNAF-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download Document Download

Product Description

  • Non-peptidic anti-diabetic agent [1].
  • Receptor-selective glucagon antagonist [1].
  • Free radical species (·OH, R·) and singlet oxygen (1O2) scavenger [2].
  • Mycotoxin [3, 4].
  • Cytotoxic [3, 4].
  • Antioxidant [2].
  • Inhibitor of botulinum neurotoxin serotype A (BoNTA) [5].
  • Anti-MRSA compound [6].
  • Antibiotic [7].

Product References

  1. Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes: J.C. Parker, et al.; Diabetes 49, 2079 (2000)
  2. Antioxidant and scavenging activity of skyrin on free radical and some reactive oxygen species: F. Vargas, et al.; Avances en Quimica 3, 7 (2008)
  3. The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce: F. Liu, et al.; Planta Med. 76, 185 (2010)
  4. A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp: K. Kawai, et al.; Toxicol. Lett. 20, 155 (1984)
  5. Fungal bis-naphthopyrones as inhibitors of Botulinum neurotoxin serotype A: J. H. Cardellina II, e. Al.; ACS Med. Chem. Lett. 3, 387 (2012)
  6. Atropisomeric dihydroanthracenones as inhibitors of multiresistant Straphylococcus aureus: R. Bara, et al.; J. Med. Chem. 56, 3257 (2013)
  7. Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera: R. Bara, et al.; J. Antibiot. 66, 491 (2013)
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