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Zinc-α-2-glycoprotein (human) Matched Pair Detection Set

Reagents for 5 x 96-well plates
AG-46B-0008-KI01 1 Set INQ
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Product Data
Synonyms Zn-α-2-GP; Zn-α-2-Glycoprotein; ZAG; ZA2G; AZGP1; ZNGP1
Application Quantitative ELISA
Specificity Detects human Zinc-α-2-glycoprotein. Does not detect mouse Zinc-α-2-glycoprotein.
Crossreactivity Human
Quantity Contains sufficient materials to run ELISAs on 5 x 96-well plates.
Sensitivity 100 pg/ml
Range 0.0156 to 1 ng/ml
Sample Type Cell Culture Supernatant, Plasma, Serum
Assay Type Sandwich
Detection Type Colorimetric
Kit Contains 1 vial standard protein (1μg) (lyophilized) [STD]
1 vial coating antibody (120μl) [COAT]
1 vial detection antibody (60μl) [DET]
1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
Product Type Kit
Shipping and Handling
Shipping BLUE ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Manual Download Document Download
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Product Description

Zinc-α-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than β2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its α1 and α2 domain helices.
<b>Standard Curve</b>
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