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AdipoGen Life Sciences
IL-36Ra (human) Matched Pair Detection Set
750
CHF
CHF 750.00
In stock
AG-46B-0006-KI011 SetCHF 750.00
Reagents for 5 x 96-well plates
| Product Details | |
|---|---|
| Synonyms | Interleukin-36 Receptor Antagonist Protein; IL-1F5; Interleukin-1 Family Member 5; IL-1δ Interleukin-1δ; Interleukin-1 Homolog 3; Interleukin-1-like Protein 1 |
| Product Type | Set |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | Detects human IL-36Ra. |
| Crossreactivity | Human |
| Quantity | Contains sufficient materials to run ELISAs on 5 x 96-well plates. |
| Sensitivity | 0.5ng/ml |
| Range | 0.78 to 50ng/ml |
| Sample Type | Cell Culture Supernatant |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Kit Contains |
1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (120μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Manual |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
Product References
- Macrophage Phenotypes in Lung Fibrosis: C.K. Koss; Diss. Univ. Konstanz (2021)
- IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice: C.K. Koss, et al.; Commun. Biol. 4, 172 (2021)
- Imbalance between IL-36 receptor agonist and antagonist drives neutrophilic inflammation in COPD: J.R. Baker, et al.; JCI Insight e155581, (2022)
- Autoantibody‑Mediated Depletion of IL‑1RA in Still’s Disease and Potential Impact of IL‑1 Targeting Therapies: M-C. Hoffmann, et al.; J. Clin. Immunol. 44, 45 (2024)
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