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Periostin (human) Matched Pair Detection Set

Reagents for 5 x 96-well plates
AG-46B-0005-KI01 1 Set INQ
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Additional Information

Product Data
Synonyms Osteoblast-specific Factor 2; OSF-2; Postn
Application Quantitative ELISA
Specificity Detects human periostin.
Crossreactivity Human
Quantity Contains sufficient materials to run ELISAs on 5 x 96-well plates.
Sensitivity 30pg/ml
Range 80 to 5000pg/ml
Sample Type Cell Culture Supernatant, Plasma, Serum
Assay Type Sandwich
Detection Type Colorimetric
Kit Contains 1 vial standard protein (0.1μg) (lyophilized) [STD]
1 vial coating antibody (120μl) [COAT]
1 vial detection antibody (60μl) [DET]
1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
Product Type Kit
Shipping and Handling
Shipping BLUE ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin up-regulation in cancers usually correlates with aggressiveness and/or poor survival. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

Product References

  1. Prognostic Value of Preoperative Serum Levels of Periostin (PN) in Early Breast Cancer (BCa): P.V. Nuzzo, et al.; Int. J. Mol. Sci. 16, 17181 (2015)
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