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BAFF, Soluble (human) ELISA Kit (hypersensitive)

AG-45B-0001-KI01 96 wells INQ
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Additional Information

Product Data
Synonyms BlyS; B Cell Activating Factor
Properties
Application Quantitative ELISA
Specificity Detects human BAFF. Does not detect mouse BAFF.
Crossreactivity Human
Quantity 1 x 96 wells
Sensitivity 8pg/ml
Range 15.6 - 500 pg/ml
Sample Type Cell Culture Supernatant, Plasma, Serum
Assay Type Sandwich
Detection Type Colorimetric
Product Type Kit
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.
Use/Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Documents
Manual Download Document Download
MSDS Download Document Download
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Product Description

BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Product References

  1. CVID-associated TACI mutations affect autoreactive B cell selection and activation: N. Romberg, et al.; J. Clin. Invest. 123, 4283 (2013)
  2. Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season: D. Frasca, et al.; Immun. Ageing 10, 14 (2013)
  3. Selective Activation of Human Dendritic Cells by OM-85 through a NF-kB and MAPK Dependent Pathway: C. Parola, et al.; PLOS One 8, e82867 (2013)
  4. Innate lymphoid cells integrate stromal and immune signals to enhance antibody production by splenic marginal zone B cells: G. Magri, et al.; Nat. Immunol. 15, 354 (2014)
  5. TACI expression and signaling in chronic lymphocytic leukemia: A. Mamara, et al.; J. Immunol. Res. 2015, 478753 (2015)
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