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AdipoGen Life Sciences
GPX3 (human) ELISA Kit
610
CHF
CHF 610.00
In stock
AG-45A-0020YEK-KI0196 wellsCHF 610.00
AG-45A-0020YTP-KI012 x 96 wellsCHF 1'100.00
Figure 1: Standard curve
| Product Details | |
|---|---|
| Synonyms | Glutathione Peroxidase 3 |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | Detects human GPX3. |
| Crossreactivity | Human |
| Quantity | 1 x 96 wells |
| Sensitivity | 100pg/ml |
| Range | 0.5 to 32ng/ml |
| Sample Type |
Cell Culture Supernatant Plasma Serum |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use. |
| Use/Stability | 12 months after the day of manufacturing. See expiry date on ELISA Kit box. |
| Documents | |
| Manual |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Glutathione peroxidase 3 (GPX3; GSHPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma.
Product References
- Dysregulation of Adipose Glutathione Peroxidase 3 in Obesity Contributes to Local and Systemic Oxidative Stress: Y.S. Lee, et al.; Mol. Endocrinol. 22, 2176 (2008)
- Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells: S.S. Chung, et al.; Mol. Cell Biol. 29, 20 (2009)
- Oxidative stress after antenatal betamethasone: Acute downregulation of glutathione peroxidase-3: J. Verhaeghe, et al.; Early Hum. Dev. 85, 767 (2009)
- Oxidant balance markers at birth in relation to glycemicand acid-base parameters: J. Verhaeghe, et al.; Metabolism 60, 71 (2011)
- Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation: R. Lobb; University Waikato (Thesis) (2011) [http://hdl.handle.net/10289/5709]
- Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression: D. Agnani, et al.; J. Ovarian Res. 4, 18 (2011)
- Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)
- Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress: A.T. Reddy, et al.; Free Rad. Biol. Med. 126, 350 (2018)
- Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis: W-J. Lee, et al.; Clin. Chim. Acta 489, 177 (2019)
- Pathological myopia-induced antioxidative proteins in the vitreous humor: Q. Wei, et al.; Ann. Transl. Med. 8, 193 (2020)
- Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study: M. Tomandlova, et al.; Free Radic. Biol. Med. 174, 66 (2021)
- Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1: R. Restuadi, et al.; Genome Med. 14, 7 (2022)
- Mitigation of benznidazole toxicity and oxidative stress following ascorbic acid supplementation in an adult traveller with chronic indeterminate Chagas’ disease: S. Van Den Broucke, et al.; J. Antimicrob. Chemother. 77, 1748 (2022)
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