AdipoGen Life Sciences

TRAIL-R1 to -R4 Flow Cytometry Pack

CHF 1'380.00
In stock
AG-44B-0004-KI011 SetCHF 1'380.00
 
More Information
Product Details
Product Type Set
Properties
Application Set Flow cytometry
Crossreactivity Human
Kit Contains 100μg each of:
anti-TRAIL-R1 (clone HS101, Prod. No. AG-20B-0022);
anti-TRAIL-R2 (clone HS201, Prod. No. AG-20B-0023);
anti-TRAIL-R3 (clone HS301, Prod. No. AG-20B-0024);
anti-TRAIL-R4 (clone HS402, Prod. No. AG-20B-0025).
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
Manual No
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-κB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
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