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AdipoGen Life Sciences
PLGF (human) (rec.)
280
CHF
CHF 280.00
In stock
AG-40T-0047-C0055 µgCHF 280.00
AG-40T-0047-C02020 µgCHF 720.00
| Product Details | |
|---|---|
| Synonyms | Placenta Growth Factor; PLGF-1; PLGF-131 |
| Product Type | Protein |
| Properties | |
| Source/Host | Sf9 cells |
| Sequence | Human PLGF (131aa). |
| Crossreactivity | Human |
| Biological Activity | Measured by its ability to bind to immobilized rhsFlt-1 in a functional ELISA. Recombinant human PLGF can bind to immobilized rhsFlt-1 (100ng/well) with a linear range at 0.5-10ng/ml. |
| MW | ~34kDa (dimer) |
| Purity | ≥95% (SDS-PAGE) |
| Reconstitution | Reconstitute with 50mM acetic acid or PBS/water. This solution can be diluted into other buffered solutions or stored frozen for future use. |
| Formulation | Lyophilized. |
| Other Product Data | UniProt link P49763: PLGF (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Human placenta growth factor-1 (PLGF-1; PLGF) binds to the receptor FLT1/VEGFR-1. It acts as a potent chemoattractant for monocytes and only as a very weak mitogen for some endothelial cell types. The physiological function in vivo is still controversial. In several reports it was shown not to be a potent mitogen for endothelial cells and not angiogenic in vivo by using different assays. It was shown that PLGF from cell culture supernatants was angiogenic in the CAM assay and in the rabbit cornea assay.
Product References
Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis: S. Ahmad, et al.; Vasc. Cell 3, 2011