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Fc (human):OX40L, Soluble (human) (rec.)

AG-40B-0172-C010 10 µg INQ
AG-40B-0172-3010 3 x 10 µg INQ
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Additional Information

Product Data
Synonyms CD252; CD134L; OX40 Ligand; TNFSF4; Tumor Necrosis Factor Superfamily Member 4; TAX Transcriptionally-activated Glycoprotein 1; TXGP1; Gp34
Properties
Source/Host HEK 293 cells
Sequence The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1.
Crossreactivity Human
Specificity Binds to human OX40 [CD134].
Biological Activity Activates T cell proliferation.
MW ~50kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data

UniProt link P23510: OX40L (human)

Product Type Protein
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
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Product Description

OX40L [CD252; TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Fc (human):OX40L, Soluble (human) (rec.) is a high activity construct in which two trimeric OX40L ligands are artificially linked via the Fc domain of human immunoglobulin.
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