AdipoGen Life Sciences

DLL3 (human) (rec.)

CHF 215.00
In stock
AG-40B-0151-C01010 µgCHF 215.00
AG-40B-0151-30103 x 10 µgCHF 430.00
More Information
Product Details
Synonyms Delta-like Protein 3; Delta3; Drosophila Delta Homolog 3
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

Extracellular domain of human DLL3 (aa 27-466) is fused at the N-terminus to a FLAG®-tag.

Crossreactivity Human
MW ~52kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test).
Concentration 0.1 mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS
Other Product Data

UniProt link Q9NYJ7: DLL3 (human)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

DLL3 (Delta-like protein 3; Delta3) inhibits primary neurogenesis. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 binds and activates Notch-1. Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1).

Product References
  1. Design and Validation of Inducible TurboCARs with Tunable Induction and Combinatorial Cytokine Signaling: RJ. Lin, et al.; Cancer Immunol. Res. 10, 1069 (2022)
  2. Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer: Y. Zhang, et al.; Clin. Cancer Res. 29, 971 (2023)
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