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AdipoGen Life Sciences
POP1 (human) (rec.)
180
CHF
CHF 180.00
In stock
AG-40B-0123-C01010 µgCHF 180.00
AG-40B-0123-30103 x 10 µgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | Pyrin Domain-containing Protein 1; PAAD-only Protein 1; Pyrin-only Protein 1; PYC1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human POP1 (aa 2-89) is fused at the N-terminus to a GST tag. |
| Crossreactivity | Human |
| MW | ~38 kDa |
| Purity | ≥95% (SDS-PAGE) |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
Uni-Prot link Q8WXC3 : POP1 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.
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