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AdipoGen Life Sciences
LIGHT, Soluble (human) (rec.)
145
CHF
CHF 145.00
In stock
AG-40B-0009-C01010 µgCHF 145.00
AG-40B-0009-30103 x 10 µgCHF 290.00
| Product Details | |
|---|---|
| Synonyms | HVEML; Tumor Necrosis Factor Ligand Superfamily Member 14; TNFSF14; CD258 |
| Product Type | Protein |
| Properties | |
| Source/Host | CHO cells |
| Sequence | Human LIGHT (aa 89-240) is fused at the N-terminus to a FLAG®-tag. |
| Crossreactivity |
Human Mouse |
| Specificity | Binds to human and mouse LTβR and human HVEM and DcR3. |
| MW | ~25kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
UniProt link O43557: LIGHT (human)AfCS Signalling Gateway link A001406: LIGHT (mouse) FLAG is a registered trademark of Sigma-Aldrich Co. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-κB, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Product References
- Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB: M. Lubrano di Ricco, et al.; Eur. J. Immunol. 50, 972 (2020)