AdipoGen Life Sciences

Annexin V (human) (rec.) (ATTO 647N)

CHF 190.00
In stock
AG-40B-0005TS-T100100 testsCHF 190.00
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Product Details
Synonyms Annexin A5; Endonexin II; Lipocortin V; Placental Anticoagulant Protein I; Calphobindin I; Vascular Anticoagulant-α
Product Type Protein
Properties
Source/Host E. coli
Sequence Recombinant human annexin V fused to a GST-tag.
Crossreactivity Human
Label/Conjugates ATTO 647N
Specificity Binds to phosphatidylserine (PS).
MW ~52kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Purity Detail Affinity purified.
Formulation Liquid. In PBS, pH 7.4, containing 0.02% sodium azide.
Other Product Data Application: This protein can be used for the detection of apoptotic cells by flow cytometry or immunofluorescence (100 tests/0.5ml). Note: A Flow Cytometry Protocol is available at www.adipogen.com.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Do not freeze.
Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
Protocols Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Product References
  1. Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity: Y. Choi, et al.; Cancer Gene Ther. 28, 960(2021)
  2. Oral Cancer Immunotherapy through a Simvastatin-Loaded Colloidal Dispersion System for the Generation of Sustained Antitumor Immunity: S.A. Kim, et al.; Adv. Ther. 4, (2021)
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