AdipoGen Life Sciences

Annexin V (human) (rec.)

CHF 205.00
In stock
AG-40B-0005-C100100 µgCHF 205.00
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Product Details
Synonyms Annexin A5; Endonexin II; Lipocortin V; Placental Anticoagulant Protein I; Calphobindin I; Vascular Anticoagulant-α
Product Type Protein
Properties
Source/Host E. coli
Sequence

Recombinant human annexin V fused to a GST-tag.

Crossreactivity Human
Specificity

Binds to phosphatidylserine (PS).

MW ~52kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Purity Detail Affinity purified.
Concentration 1mg/ml after reconstitution.
Reconstitution Reconstitute with 100µl sterile water.
Formulation Lyophilized. In PBS.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Repeated freeze/thaw cycles (>3) may result in an adverse effect on the activity.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Reconstituted solutions can be kept at 4°C under sterile conditions for one week or should be frozen in aliquots at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Product References
  1. Role of phosphatidylserine receptors in enveloped virus infection: K. Morizono & I.S.Y. Chen; J. Virol. 88, 4275 (2014)
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