AdipoGen Life Sciences

Progranulin (rat) (rec.) (untagged)

CHF 220.00
In stock
AG-40A-0196Y-C01010 µgCHF 220.00
AG-40A-0196Y-C05050 µgCHF 520.00
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Product Details
Synonyms Proepithelin; PEPI; PC Cell-derived Growth Factor
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa.

Crossreactivity Rat
MW ~90kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 50µg size: 1 mg/ml
Reconstitution 10µg size: Reconstitute with 100µl sterile water.
50µg size: Reconstitute with 50µl sterile water.
PBS containing at least 0.1% BSA should be used for further dilutions.
Formulation Lyophilized. Contains PBS.
Other Product Data

NCBI Gene link NP_058809: Granulin (rat)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Centrifuge lyophilized vial before opening and reconstitution.
Do not freeze/thaw.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Product References
  1. Effect of Progranulin on Proliferation and Differentiation of Neural Stem/Progenitor Cells after Oxygen/Glucose Deprivation: I. Horinokita, et al.; Int. J. Mol. Sci. 23, 1949 (2022)
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