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AdipoGen Life Sciences
CTRP5 (human) (rec.) (His)
230
CHF
CHF 230.00
In stock
AG-40A-0142-C01010 µgCHF 230.00
AG-40A-0142-C05050 µgCHF 575.00
Figure 1: Recombinant human CTRP5 (Prod. No. AG-40A-0142) activates AMPK signaling pathway in rat L6 myoblastes.
Differentiated rat L6 myoblastes were stimulated with control buffer or 0.5μg/ml recombinant human CTRP5 for 30min. The cell lysate was subjected to do immunoblotting with antibodies against pAMPK and total AMPK.
Differentiated rat L6 myoblastes were stimulated with control buffer or 0.5μg/ml recombinant human CTRP5 for 30min. The cell lysate was subjected to do immunoblotting with antibodies against pAMPK and total AMPK.
| Product Details | |
|---|---|
| Synonyms | Complement C1q Tumor Necrosis Factor-related Protein 5; C1QTNF5 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human CTRP5 (aa 16-243) is fused at the N-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~26kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <1EU/μg purified protein (LAL test; Lonza). |
| Reconstitution | Reconstitute in distilled water. |
| Formulation | Lyophilized from a 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Other Product Data | UniProt link Q9BXJ0: Complement C1q tumor necrosis factor-related protein 5 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
Product References
- Regulation and Function of C1Q/TNF-related Protein-5 (CTRP-5) in the Context of Adipocyte Biology: A.Schmid, et al.; Exper. Clin. Endocrinol. Diab. 121, 310 (2013)
- CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis: C. Li, et al.; Atherosclerosis 278, 197 (2018)
- AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration: K.J. Miyagishima, et al.; Nature Comm. Biol. 4, 1360 (2021)