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AdipoGen Life Sciences
ANGPTL7 (human) (rec.)
265
CHF
CHF 265.00
In stock
AG-40A-0060-C01010 µgCHF 265.00
AG-40A-0060-C05050 µgCHF 790.00
Figure 1: ERK phosphorylation induced by hANGPTL7 in THP-1 cells.
THP-1 monocyte cells were serum starved for 16hr and then stimulated with ANGPTL7 (human) (rec.) (Prod. No. AG-40A-0060) (500ng/ml) for 1, 2 and 3 hrs, respectively. Antibodies against pERK1/2 & total ERK1/2 were used for immunoblotting.
THP-1 monocyte cells were serum starved for 16hr and then stimulated with ANGPTL7 (human) (rec.) (Prod. No. AG-40A-0060) (500ng/ml) for 1, 2 and 3 hrs, respectively. Antibodies against pERK1/2 & total ERK1/2 were used for immunoblotting.
| Product Details | |
|---|---|
| Synonyms | Angiopoietin-like Protein 7; Cornea-derived Transcript 6 Protein; CDT6 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence | Human ANGPTL7 (aa 1-346) is fused at the C-terminus to a FLAG®-tag. |
| Crossreactivity | Human |
| Biological Activity | Activates ERK phosphorylation in THP-1 cells. |
| MW | ~45kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.5 mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS. |
| Other Product Data |
UniProt link O43827: ANGPTL7 (human) [Precursor]
FLAG is a registered trademark of Sigma-Aldrich Co. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
ANGPTL7 (Angiopoietin-like protein 7) is expressed in various tissues and regulates angiogenesis. Human ANGPTL7 was characterized as a potent target gene of the WNT/β-catenin signaling pathway, and is a pharmacogenomics target in the fields of oncology and regenerative medicine. Overexpression of ANGPTL7 increases collagen expression and might exert a pathogenic role in glaucoma.
Product References
- Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors: H.E. Broxmeyer, et al.; Blood Cells Mol. Dis. 48, 25 (2012)
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