CD137 (mouse):Fc (human) (recombinant protein)

Specifications / Handling

More Information
Product Details
Synonyms	4-1BB; TNFRSF9
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	The extracellular domain of mouse CD137 (aa 1-185) is fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity	Mouse
MW	~50kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.1EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml
Formulation	Liquid. 0.2μm filtered solution in PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	UniProt link P20334: CD137 (mouse) (precursor)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.

Product References

Involvement of CD137 Ligand Signaling in Neural Stem Cell Death: C.H. Yun, et al.; Mol. Cells 36, 245 (2013)

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CD137 (mouse):Fc (human) (rec.)