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CD137L, Soluble (mouse) (rec.)

Replaces AG-40A-0020
AG-40A-0020Y-C050 50 µg INQ
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Additional Information

Product Data
Synonyms 4-1BBL; TNFSF9
Properties
Source/Host HEK 293 cells
Sequence The extracellular domain of mouse CD137L (aa 104-309) is fused at the N-terminus to a FLAG®-tag.
Crossreactivity Mouse
Specificity Binds to mouse CD137.
MW ~40kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Reconstitution Reconstitute with 50μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data

UniProt link P41274: CD137L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.

Product Type Protein
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download Document Download
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Product Description

The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
mCD137L-FLAG<sup>®</sup> binding to CD137 transfected cells.<br />HEK 293 cells were transiently transfected with a construct encoding full-length mouse CD137. At 48hrs after transfection, the transfectants were incubated with 0.5 or 5&mu;g/ml CD137L, Soluble (mouse) (rec.) (Prod. No. AG-40A-0020Y) and followed by flow cytometry analysis with anti-FLAG<sup>®</sup> M2-FITC.
mCD137L-FLAG® binding to CD137 transfected cells.
HEK 293 cells were transiently transfected with a construct encoding full-length mouse CD137. At 48hrs after transfection, the transfectants were incubated with 0.5 or 5μg/ml CD137L, Soluble (mouse) (rec.) (Prod. No. AG-40A-0020Y) and followed by flow cytometry analysis with anti-FLAG® M2-FITC.
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