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anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-3)

AG-27B-0017-C100 100 µg INQ
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Additional Information

Product Data
Synonyms A Proliferation Inducing Ligand; TNFSF13; CD256; TALL-2
Properties
Clone Apry-1-3
Isotype Human IgG1λ
Source/Host Purified from HEK 293 cell culture supernatant.
Immunogen/Antigen Mouse APRIL (aa 98-232).
Application ELISA
Immunoprecipitation: (1:200)
Functional: Inhibits the binding of mouse APRIL to BCMA and TACI.
Crossreactivity Mouse
Specificity Recognizes mouse APRIL. Does not recognize mouse BAFF.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein A-affinity purified.
Endotoxin Content <0.01EU/μg purified protein (LAL-test; Lonza)
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Other Product Data APRIL (mouse) monoclonal antibody (recombinant) (blocking) (APRY-1-3) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the human lgG1 Fc domain.
Product Type Recombinant Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes.

Anti-APRIL (mouse) Monoclonal Antibody (recombinant) (Blocking) (APRY-1-3) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
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