Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
anti-NFATc2 (human), pAb (IG-209)
560
CHF
CHF 560.00
In stock
AG-25T-0111-C02020 µgCHF 560.00
| Product Details | |
|---|---|
| Synonyms | Nuclear Factor of Activated T Cells; Cytoplasmic 2; NF-ATc2; NF-ATp |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant full-length human NFATc2 fused to a GST-tag. |
| Application |
ChIP: (1:100) |
| Crossreactivity | Human |
| Specificity |
Recognizes human NFATc2. |
| Purity | Antigen affinity purified. |
| Concentration | 200μg/ml |
| Formulation | Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. |
| Isotype Negative Control | |
| Accession Number | UniProt ID Q13469: NFATc2 human |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
NFATc2 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of IL-2, IL-3, IL-4, TNF-α or GM-CSF. It promotes invasive migration through the activation of GPC6 expression and the WNT5A signaling pathway.
Product References
- Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006)
- Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008)
- Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter: S. Klein-Hessling, et al.; J. Biol. Chem. 283, 31030 (2008)
- NFAT but not NF-B is critical for transcriptional induction of the pro-survival gene A1 following igE receptor activation in mast cells: E. Ulleras, et al.; Blood 111, 3081 (2008)
- Autoregulation of Th1-mediated inflammation by twist1: U. Niesner, et al.; J. Exp. Med. 205, 1889 (2008)
- CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation: I. Zanoni, et al.; Nature 460, 264 (2009)
- Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells: H. Flach, et al.; Immunity 33, 723 (2010)
- NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network: S. Bhattacharyya, et al.; J. Exp. Med. 208, 823 (2011)
- Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis: K. Gerlach, et al.; Cancer Res. 72, 4340 (2012)
- Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells: M. Vaeth, et al.; PNAS 109, 16258 (2012)
- An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development: A.K. Patra, et al.; Nat. Immunol. 14, 127 (2013)
Related Products
