AdipoGen Life Sciences

anti-LYVE-1 (mouse), pAb

CHF 320.00
In stock
AG-25T-0102-C100100 µgCHF 320.00
More Information
Product Details
Synonyms Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1; CRSBP-1
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Recombinant mouse soluble LYVE-1 (aa24-228).
Application

ELISA: (1-15μg/ml)
Flow Cytometry: (3-10μg/ml)
Immunohistochemistry: (frozen sections; paraffin sections)
Western Blot: (2-5μg/ml)
Optimal conditions must be determined individually for each application.

Crossreactivity Mouse
Specificity

Recognizes mouse LYVE-1.

Purity Protein A purified.
Purity Detail Protein A purified.
Formulation Lyophilized.
Reconstitution Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml.
Isotype Negative Control

Rabbit IgG

Other Product Data

UniProt ID Q8BHC0: Lyve-1 (mouse)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

Product References
  1. The Sialomucin CD34 Is a Marker of Lymphatic Endothelial Cells in Human Tumors: U. Fidler, et al.;  Am. J. Pathol. 168, 1045 (2006)
  2. Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis: L. Carramolino, et al.; Circ. Res. 106, 1197 (2010)
  3. Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone: S. Oe, et al.; J. Biomed. Material Res. A 109, 1220 (2021)
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