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anti-PARP-1 [ARTD1] (human), pAb

AG-25T-0002-R100 100 µl $210.00
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Additional Information

Product Data
Synonyms Poly(ADP-ribose) Polymerase 1; ADP-ribosyltransferase Diphtheria Toxin-like 1; NAD(+) ADP-ribosyltransferase 1
Properties
Source/Host Rabbit
Immunogen/Antigen Recombinant human PARP-1 [ARTD1] (aa 215-525).
Application Immunocytochemistry: 1:500-1:1'000
Immunohistochemistry: 1:500-1:1'000
Immunoprecipitation: 2μl per 100μg nuclear extract
Western Blot: 1:2'000-1:5'000
Optimal conditions must be determined individually for each application.
Crossreactivity Human, Monkey, Mouse
Specificity Recognizes human PARP-1. Cross-reacts weakly with mouse and monkey PARP-1.
Formulation Liquid. Contains 0.1% sodium azide.
Other Product Data UniProt ID P09874: PARP-1 (human)
Product Type Polyclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Description

PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-γ to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

Product References

  1. Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice: V. Petrilli, et al.; J. Clin. Invest. 114, 1072 (2004)
  2. Acetylation of PARP-1 by p300/CBP regulates coactivation of NF-kappa B-dependent transcription: P.O. Hassa, et al.; J. Biol. Chem. 280, 40450 (2005)
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