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AdipoGen Life Sciences
anti-Cornulin (human), pAb (SZ1229)
240
CHF
CHF 240.00
In stock
AG-25B-0016-C05050 µgCHF 240.00
Figure 1: Immunohistochemistry detection of human cornulin using anti-Cornulin (human), pAb (SZ1229) (Prod. No. AG-25B-0016). Method: Staining performed on frozen sections of esophagus (H), foreskin (A-C) and scalp (D-G) using anti-Cornulin (human), pAb (SZ1229) at 1:100 in PBS containing 12% BSA. Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle (arrows, D–F), in normal esophagus, the staining is localized in the granular and lower cornified cell layers with a peripheral localization (arrows). Control sections (C and G) show no staining.
| Product Details | |
|---|---|
| Synonyms | Tumor Related Protein; C1orf10 Gene Product; Chromosome 1 Open Reading Frame 10 Gene Product |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen |
Synthetic peptide corresponding to aa 259-274 (E259ATNDQNRGTETHGQG274) of human cornulin. |
| Application |
Immunohistochemistry: (frozen sections: 1:100) |
| Crossreactivity | Human |
| Specificity |
Recognizes human cornulin. Detects a band of ~70kDa by Western blot. |
| Concentration | 0.5mg/ml |
| Formulation | Liquid. In PBS containing 1% BSA and 0.01% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines. It attenuates deoxycholic acid (DCA)-induced apoptotic cell death and the release of calcium. In overexpressed oral squamous carcinoma cell lines, cornulin negatively regulates cell proliferation by the induction of G1 arrest.
Product References
- Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation: R. Contzler, et al.; J. Invest. Dermatol. 124, 990 (2005)
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