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AdipoGen Life Sciences
anti-TRAM (human), pAb (AL239)
130
CHF
CHF 130.00
In stock
AG-25B-0011-R05050 µlCHF 130.00
| Product Details | |
|---|---|
| Synonyms | TRIF-related Adapter Molecule; TIRP; Toll-Interleukin 1 Receptor [TIR] Domain-containing Protein; TICAM-2; TIR-containing Adapter Molecule-2 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Synthetic peptide corresponding to aa 2-29 (G2IGKSKINSCPLSLSWGKRHSVDTSPGY29) of human TRAM. |
| Application |
Western Blot: (1:1'000) Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS. |
| Crossreactivity | Human |
| Specificity |
Recognizes human TRAM. |
| Formulation | Liquid. Neat serum containing 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-κB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.
Product References
- Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood 109, 2887 (2007)