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AdipoGen Life Sciences
anti-Podoplanin (human), mAb (18H5)
460
CHF
CHF 460.00
In stock
AG-20T-0100-C100100 µgCHF 460.00
| Product Details | |
|---|---|
| Synonyms | Glycoprotein 36; PA2.26 Antigen; Aggrus |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 18H5 |
| Isotype | Mouse IgG1 |
| Immunogen/Antigen | MDCK cells stably expressing podoplanin. |
| Application |
Flow Cytometry: (1-10μg/ml) |
| Crossreactivity | Human |
| Specificity |
Recognizes human podoplanin. |
| Purity | Protein G purified. |
| Purity Detail | Protein G-affinity purified. |
| Formulation | Lyophilized. |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
Product References
- Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade: F. Spinella, et al.; Cancer Res. 69, 2669 (2009)
- Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor: S. Fiorentini, et al.; J. Gen. Virol. 92, 650 (2011)
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