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anti-MPC-2, mAb (JCM-1)

AG-20B-0071-C100 100 µg INQ
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Additional Information

Product Data
Synonyms Mitochondrial Pyruvate Carrier 2; Brain Protein 44
Properties
Clone JCM-1
Isotype Mouse IgG2bκ
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Peptide coupled to KLH.
Application Western Blot: (1µg/ml)
Immunoprecipitation: (1:200)
Immunocytochemistry: (1:400) (see online protocol)
Crossreactivity Human, Mouse
Specificity Recognizes endogenous human and mouse MPC-2.
Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 25% glycerol and 0.02% sodium azide.
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
Protocols Download Document Download
MSDS Download Document Download

Product Description

Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Two proteins, mitochondrial pyruvate carriers MPC-1 and MPC-2, form a heterooligomeric complex in the IMM to facilitate pyruvate transport. This step is required for mitochondrial pyruvate oxidation and carboxylation-critical reactions in intermediary metabolism that are dysregulated in several common metabolic diseases.

Product References

  1. Monitoring mitochondrial pyruvate carrier activity in real time using a BRET-based biosensor: Investigation of the Warburg Effect: V. Compan, et al.; Mol. Cell 59, 491 (2015)
  2. MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells: B. Vanderperre, et al.; J. Biol. Chem. 291, 16448 (2016)
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