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anti-IL-38, mAb (Nhat-1)

AG-20B-0070-C100 100 µg INQ
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Additional Information

Product Data
Synonyms Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
Properties
Clone Nhat-1
Isotype Mouse IgG2bκ.
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant human IL-38.
Application Western Blot: (1:1'000)
ICC: (1:500)
ELISA: (1:2'000)
Crossreactivity Human, Mouse
Specificity Recognizes human and mouse IL-38.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein A affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
Mouse and human IL-38 is detected using anti-IL-38, mAb (Nhat-1) (AG-20B-0070).<br /><b>Method:</b> Recombinant mouse IL-38 (AG-40B-0101) (lane 1), cell extracts from HEK 293 cells mock-transfected (lane 2) or transfected with human IL-38 (lane 3) were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with anti-IL-38, mAb (Nhat-1) (1µg/ml). Proteins are visualized by a chemiluminescence detection system.
Mouse and human IL-38 is detected using anti-IL-38, mAb (Nhat-1) (AG-20B-0070).
Method: Recombinant mouse IL-38 (AG-40B-0101) (lane 1), cell extracts from HEK 293 cells mock-transfected (lane 2) or transfected with human IL-38 (lane 3) were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with anti-IL-38, mAb (Nhat-1) (1µg/ml). Proteins are visualized by a chemiluminescence detection system.
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