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AdipoGen Life Sciences
anti-IL-36β (human), mAb (Jacky-1)
470
CHF
CHF 470.00
In stock
AG-20B-0069-C100100 µgCHF 470.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-36β Interleukin-1 Family Member 8; IL-1F8 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | Jacky-1 |
| Isotype | Mouse IgG1κ |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Recombinant human IL-36β. |
| Application |
Western Blot: (1:1'000) |
| Crossreactivity | Human |
| Specificity |
Recognizes human IL-36β. Does not cross-react with mouse IL-36β and IL-36γ. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein A affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
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