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anti-AIM2 (human), mAb (3B10)

AG-20B-0040-C100 100 µg INQ
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Additional Information

Product Data
Synonyms Interferon-inducible Protein AIM2; Absent in Melanoma 2
Properties
Clone 3B10
Isotype Mouse IgG1
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Human AIM2 (aa 1-186).
Application ICC: (1:200)
Western Blot: (1:1000)
Crossreactivity Human
Specificity Recognizes human AIM2.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Endotoxin Content
Concentration 1 mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Other Product Data UniProt link O14862: AIM2 (human)
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16 [8], MNDA [9], AIM2 [1] and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1β.

Product References

  1. Expression of IFI 16 in epithelial cells and lymphoid tissues: W. Wei, et al.; Histochem. Cell Biol. 119, 45 (2003)
  2. Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2: K.S. Cresswell, et al.; BBRC 326, 417 (2005)
  3. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA: T. Fernandes-Alnemri, et al.; Nature 458, 509 (2009)
  4. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC: V. Hornung, et al.; Nature 458, 514 (2009)
  5. A novel flow cytometric method to assess inflammasome formation: D.P. Sester, et al.; J. Immunol. 194, 455 (2015)
  6. Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection: C. Sun, et al.; J. Immunol. 194, 1819 (2015)
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