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AdipoGen Life Sciences
anti-NMNAT2 (human), mAb (Nady-1)
110
CHF
CHF 110.00
In stock
AG-20A-0087-C05050 µgCHF 110.00
AG-20A-0087-C100100 µgCHF 190.00
Figure 1: Immunohistochemical staining of NMNAT2 using anti-NMNAT2 (human), mAb (Nady-1) (Prod. No. AG-20A-0087) in human brain cortex tissue (10µg/ml).
This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.
This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.
Figure 2: Western blot analysis using anti-NMNAT2 (human), mAb (Nady-1) (Prod. No. AG-20A-0087) at 1:2'000 dilution.
1: Human NMNAT2 (His-tagged).
2: Human NMNAT3 (His-tagged).
3: Unrelated (His-tagged) (negative control).
1: Human NMNAT2 (His-tagged).
2: Human NMNAT3 (His-tagged).
3: Unrelated (His-tagged) (negative control).
| Product Details | |
|---|---|
| Synonyms | Nicotinamide Mononucleotide Adenylyltransferase 2; NMN Adenylyltransferase 2; NaMN Adenylyltransferase 2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | Nady-1 |
| Isotype | Mouse IgG1κ |
| Immunogen/Antigen | Recombinant human NMNAT2. |
| Application |
ELISA: (direct and indirect: 1:2’000-1:5’000) Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS. |
| Crossreactivity | Human |
| Specificity |
Recognizes human NMNAT2. |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
NMNAT2 catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. Has been shown to correlate with Alzheimer’s disease in APPswe/PS1dE9 transgenic mice and delayed wallerian degeneration in cultured superior cervical ganglia (SCGs) from morphological changes, microtubule destruction and neurofilament degradation.
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