AdipoGen Life Sciences

anti-CD137 (mouse), mAb (M4173)

CHF 270.00

In stock

AG-20A-0072-C05050 µgCHF 270.00

Figure 1: A) FACS: Mouse CD137-transfected HEK 293 cells were stained significantly using anti-CD137 (mouse), mAb (M4173) (Prod. No. AG-20A-0072). No binding was detected on empty vector transfected cells. B) FACS: Mouse T lymphocyte cells (treated Con A) were stained significantly using anti-CD137 (mouse), mAb (M4173) (Prod. No. AG-20A-0072).

Specifications / Handling

More Information
Product Details
Synonyms	4-1BB; TNFRSF9
Product Type	Monoclonal Antibody
Properties
Clone	M4173
Isotype	Rat IgG1κ
Immunogen/Antigen	Recombinant mouse CD137.
Application	Flow Cytometry: (1:500) Western Blot: (1:2’000) Optimal conditions must be determined individually for each application.
Crossreactivity	Mouse
Specificity	Recognizes mouse CD137. Detects a band of ~40kDa by Western blot. Does not cross-react with human CD137.
Purity Detail	Protein G-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control	Rat IgG1 Isotype Control
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

CD137 is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.

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