AdipoGen Life Sciences

anti-CD137L (human), mAb (41B436)

CHF 310.00

In stock

AG-20A-0031-C05050 µgCHF 310.00

AG-20A-0031-C100100 µgCHF 390.00

Figure 1: FACS: Human CD137L-transfected HEK 293 cells were stained significantly using anti-CD137L (human), mAb (41B436) (Prod. No. AG-20A-0031). No binding was detected on empty vector transfected cells.

Figure 2: Western blot analysis of human CD137L using anti-CD137L (human), mAb (41B436) (Prod. No. AG-20A-0031) at 1:2,000dilution.
1: Recombinant humanCD137L (FLAG^®-tagged).
2: Recombinant mouse CD137L (FLAG^®-tagged).

Specifications / Handling

More Information
Product Details
Synonyms	4-1BBL; TNFSF9
Product Type	Monoclonal Antibody
Properties
Clone	41B436
Isotype	Mouse IgG1κ
Immunogen/Antigen	Recombinant human CD137L extracellular domain.
Application	ELISA: (direct or indirect: 1:500-1:5'000) Flow Cytometry: (1:1'000) Immunocytochemistry: (see reference Nr. 2) Western blot: (1:2'000) Optimal conditions should be determined individually for each application.
Crossreactivity	Human
Specificity	Recognizes extracellular domain of human CD137L. Does not cross-react with mouse CD137L.
Purity Detail	Protein G-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control	Mouse IgG1 Isotype Control
RRID	AB_2490113
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

Product References

Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling: C. Gullo, et al.; PLoS One. 5, e10845 (2010)
Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling: M.C. Moh, et al.; FASEB J. 27, 2957 (2013)
Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression: W.T. Ho, et al.; Cancer Res. 73, 652 (2013)

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