Chemodex

Amikacin hydrate

CHF 122.00
In stock
CDX-A0287-G0055 gCHF 122.00
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Product Details
Synonyms N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A; Amicacin; Amikacillin; Amukin; Antibiotic BB-K 8; BAY 41-6551; BAY 416651
Product Type Chemical
Properties
Formula

C22H43N5O13 . xH2O

MW 585.60 (anhydrous basis)
CAS 1257517-67-1 | 37517-28-5 (anhydrous)
RTECS WK1955000
Source/Host Chemicals Semisynthetic
Purity Chemicals ≥97% (NMR)
Appearance White crystalline powder.
Solubility Soluble in water (10mg/ml).
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key LKCWBDHBTVXHDL-RMDFUYIESA-N
Smiles O[C@@H]1[C@@H](CN)O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](NC([C@H](CCN)O)=O)C[C@@H]2N)[C@H](O)[C@H]1O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Broad-spectrum semisynthetic aminoglycoside antibiotic derived from kanamycin A, which is effective against Gram-negative and Gram-positive bacteria. Aminoglycoside antibiotics bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation, consequently inhibiting bacterial protein synthesis. Commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (ASTs, panels, discs, and MIC strips) of organisms such as Mycobacterium tuberculosis and Ehrlichia phagocytophila.

Product References

(1) H. Kawaguchi, et al.; J. Antibiot. 25, 695 (1972) | (2) K.E. Price, et al.; Antimicrob. Agents Chemother. 5, 143 (1974) | (3) N.S. Brewer; Mayo Clin. Proc. 52, 675 (1977) | (4) R.N. Jones, et al.; Antimicrob. Agents Chemother. 22, 985 (1982) | (5) A.M. Ristuccia & B.A. Cunha; Ther. Drug Monit. 7, 12 (1985) | (6) B.D. Davis; Microbiol. Rev. 51, 341 (1987) | (7) B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006) | (8) M.S. Ramirez & M.E. Tolmasky; Molecules 22, E2267 (2017)

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