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anti-Glutamine Synthetase, pAb

YIF-LF-PA0100 100 µl INQ
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MSDS

Additional Information

Product Data
Synonyms GS; GLNS; GLUL; EC=6.3.1.2; EC=4.1.1.15; Glutamine Synthetase; Glutamate Decarboxylase; Glutamate-Ammonia Ligase
Properties
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application Western Blot (1:2,000)
Immunoprecipitation not tested.
Crossreactivity Human, Mouse, Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Polyclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

Glutamine Synthetase (GS) catalyzes the conversion of ammonia and glutamate to glutamine. This reaction consumes a molecule of ATP: Glutamate + NH4+ + ATP -> Glutamine + ADP + Pi GS is found in astrocytes as an octamer of identical 45kDa subunits. Most well known function of GS is the detoxification of brain ammonia. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer’s disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. On the other hands, the level of expression of GS is increased during ischemia in vivo or hypoxia in culture. Essential for proliferation of fetal skin fibroblasts.

Product References

1) Suarez, I. et al. (2002) Neurochemistry International, 41: 123-142. (General)
2) Kosenko, E. et al (2003) Neurochemistry International, 43: 493-499. (General)
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