Call +41-61-926-60-40 Fax +41-61-926-60-49

anti-Thioredoxin 2, pAb

YIF-LF-PA0012 100 µl INQ
Actions
Select size:

* Required Fields

Amount:
Add to Cart
Call +41-61-926-60-40
Fax +41-61-926-60-49
Contact Us!
MSDS

Additional Information

Product Data
Synonyms TXN2; MTRX; TRX2; Mt-Trx; Thioredoxin-2; Thioredoxin, Mitochondrial
Properties
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application Western Blot (1:5,000~1:10,000)
Crossreactivity Human, Mouse, Rat
Purity Detail Affinity purification.
Concentration 1 mg/mL
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Polyclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds (1). Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations (2). Specific protein disulfide targets for reduction by Trx include protein disulfide –isomerase (PDI) (3) and a number of transcription factors such as p53 (4), NF-κB (5) and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins (6-7). Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.

Product References

1) Andoh, T. et al. (2002) J.Biol.Chem. 277, 9655-9660. (General)
2) Arner, E. S. and Holmgren, A. (2000) Eur. J. Biochem. 267, 6102-6109. (General)
3) Lundstrom, J. and Holmgren, A. (1990) J. Biol. Chem. 265, 1994-9120. (General)
4) Nordberg, J. and Arner, E. S. J. (2001) Free Radic. Biol. Med. 31, 1287-1312. (General)
5) Matthews, J. R. et al. (1992) Nucleic Acids Res. 20, 3821-3830. (General)
6) Wei, S. J. (2000) Cancer Res. 60, 6688-6695. (General)
7) Chae, H. Z. (1999) Methods Enzymol. 300, 219-226. (General)
No reviews for this product yet.