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anti-Casein Kinase II α, mAb (8E5)

YIF-LF-MA0223 100 µl INQ
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Additional Information

Product Data
Synonyms CK2A1; CSNK2A1; EC=2.7.11.1; CK II α; Casein Kinase II Subunit α
Properties
Clone 8E5
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human His-Casein kinase II a protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Immunoprecipitation (1 μl)
Crossreactivity Human, Mouse, Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

The casein kinase I (CKI) family of serine/threonine protein kinases is highly conserved from yeast to humans. The CKI family is involved in many diverse and important cellular functions, such as regulation of membrane transport, cell division, DNA repair, circadian rhythms, and nuclear localization. The name of the enzyme family was originated from the convenience of casein as a substrate since the earliest days of research on protein phosphorylation. Casein kinase 2 (CK2) is a ubiquitous, highly conserved, essential serine/threonine kinase which has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. CK2 is a tetramer of two α subunits and two β subunits. The α subunits have the catalytic kinase domain. Loss of the α‘ catalytic subunit produces male infertility, and loss of the single β regulatory subunit is early embryonic lethal. CK2 appears to be upregulated in most cancers and the promotion of tumorigenesis by the overexpression of CK2 has been reported in transgenic mice. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The α and α' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.

Product References

1) Price M.A., 2006 Genes Dev. 20:399-410. (General)
2) Seldin DC et al., (2005) Mol Cell Biochem. 274(1-2):63-67. (General)
3) Tobin A.B., (2002) Trends Pharmacol Sci. 23:337-343. (General)
4) Gross S.D. and Anderson R.A., (1998) Cell Signal. 10:699-711. (General)
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