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anti-Transthyretin, mAb (10E1)

YIF-LF-MA0174 100 µl INQ
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Additional Information

Product Data
Synonyms TTR; ATTR; PALB; TBPA; Prealbumin; Transthyretin
Properties
Clone 10E1
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human protein purified from E. coli .
Application Western Blot (1:2,000)
Immunoprecipitation (3 μl)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

Transthyretin (TTR, 55 kDa homotetramer) is a thyroid hormone-binding protein that transports thyroxine (T4) from the bloodstream to the brain. TTR was originally called prealbumin because it ran faster than albumin on electrophoresis gels. TTR is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine. TTR is suggested that plays an essential role in brain function. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Product References

1) Palha JA. Clin Chem Lab Med. (2002) vol.40(12): pp.1292-300. (General)
2) Hamilton JA, Benson MD. Cell Mol Life Sci. (2001) vol.58(10): pp.1491-521. (General)
3) Hund E, et al, Neurology. (2001) vol.56(4): pp.431-5. (General)
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