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anti-Ceruloplasmin, mAb (3B11)

YIF-LF-MA0159 100 µl INQ
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Additional Information

Product Data
Synonyms CP; EC=1.16.3.1; Ferroxidase; Ceruloplasmin
Properties
Clone 3B11
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application ELISA
Western Blot (1:1,000)
Immunoprecipitation (1 μl)
IHC-P
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

Ceruloplasmin, 132kDa, is a serum ferroxidase that contains greater than 95% of the copper found in plasma. This protein is a member of the multicopper oxidase family, an evolutionarily conserved group of proteins that utilize copper to couple substrate oxidation with the four-electron reduction of oxygen to water. Despite the need for copper in ceruloplasmin function, this protein plays no essential role in the transport or metabolism of this metal. Serum ceruloplasmin level is reduced in Wilson's disease, malnutrition nephrotic syndrome and increased in pregnancy, oestrogen containing contraceptives, acute infection, some types of chronic liver disease, malignancy, rheumatoid arthritis. Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane.

Product References

1) Hellman NE, Gitlin JD. Annu Rev Nutr. (2002); vol.22: pp.439-58. (General)
2) Loeffler DA et al, Free Radic Res. (2001) ; vol.35(2): pp.111-8. (General)
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