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anti-CRP, mAb (26D7)

YIF-LF-MA0143 100 µl INQ
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Additional Information

Product Data
Synonyms CRP; PTX1
Properties
Clone 26D7
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Crossreactivity Human, Mouse, Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Origin Manufactured by AbFrontier
Product Type Monoclonal Antibody
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

Product Description

C reactive protein (CRP) is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (M.W 24kDa) that are bound noncovalently to form the physiologic CRP molecule(M.W. 117.5kDa). CRP binds to several nuclear components, including chromatin and histones. This may indicate that it functions as a scavenger during cell necrosis. CRP also appears to have the strongest association with cardiovascular events; It may, therefore, be associated with ischemic heart disease. Its rapid increase in synthesis within hours after tissue injury or infection suggests that it contributes to host defense and that it is part of the innate immune response. Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Product References

1) Steven Black et. al. (2004) The J of Biol Chem 279(47) : 48487-48490. (General)
2) Edward T.H. Yeh (2004) circulation 109[suppl II]:II-11-II-14. (General)
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